Massey Grand Rounds: Conversations with Dr. David Malkin

PROFYLEing Cancer for KiCS: A Brief Look into the Future of Precision Oncology

This event will be held via zoom webinar. To attend, please register here. 

Meeting Objectives:

1) To appreciate the impact that next generation sequencing platforms have had on care of
children/adolescents/young adults (CAYA) diagnosed with cancer.

2) To understand the cost-benefit complexities of introduction of NGS and targeted therapies for CAYA
with cancer.

3) To recognize the career trajectory of a clinician-scientist from medical student to leader of a national
multi-disciplinary, multi-institutional program in precision medicine.

Dr. Malkin received his medical degree from the University of Toronto in 1984 and completed his residency in paediatrics and paediatric hematology/oncology at The Hospital for Sick Children in Toronto. He completed post-doctoral research training in molecular genetics at Massachusetts General Hospital, Harvard University, where he discovered the link between germline mutations in the TP53 tumor suppressor gene and the Li-Fraumeni cancer susceptibility syndrome. Dr. Malkin returned to Canada to accept a faculty position at SickKids and University of Toronto in 1992. Dr. Malkin is Professor of Pediatrics and Medical Biophysics in the Temerty Faculty of Medicine, University of Toronto. He holds the CIBC Children’s Foundation Chair in Child Health Research, is a Senior Staff Oncologist in the Division of Hematology/Oncology, Director of the Cancer Genetics program, and a Senior Scientist in the Genetics and Genome Biology Program at The Hospital for Sick Children in Toronto. Dr. Malkin is the Lead of the SickKids Precision Child Health initiative. He is co-Director of the SickKids Cancer Sequencing (KiCS) program which integrates and translates next generation sequencing into clinical care of children with cancer, and Director of the pan-Canadian multi-institutional PRecision Oncology For Young peopLE (PROFYLE) initiative which is establishing a pipeline to incorporate next generation sequencing into novel clinical trials (‘precision oncology’) for children and young adults with hard-to-treat cancers across Canada. Dr. Malkin’s research program focuses on genetic and genomic mechanisms of childhood cancer susceptibility which he has explored particularly in the context of TP53 and Li-Fraumeni syndrome. Recently, his work has addressed the application of genomics to develop rational clinicalsurveillance and treatment guidelines for children and adults at genetic ‘high risk’ for cancer. He has published over 250 peer-reviewed articles and has received several awards recognizing his dedication to clinical care, advocacy, research, medical education and mentorship. His research has been funded by the Terry Fox Research Institute, Canadian Cancer Society, Canadian Institutes for Health Research, Canada Foundation for Innovation, Genome Canada, the National Institutes of Health (US) and the Department of Defense (US).

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